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KMID : 0356919930260051046
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Korean Journal of Anesthesiology
1993 Volume.26 No. 5 p.1046 ~ p.1050
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A Case Report of Anaphylactoid Reaction for Thiopental
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Abstract
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Sodium thiopental is a popular intravenous anesthetic that has been used extensively throughout the world.
The rare adverse reactions to thiopental consist mainly of anaphylactic shock, bronchospasm, and local thrombophlebitis.
The reported incidence of presumed anaphylactic reaction (Type I hypersensitivity) to thiopental are extremely rare.
Although the mechanism of these adverse reactions in unclear, the clinical features (generalized erythema, hypotension, edema and bronchspasm) are thought to result from massive discharge of histamine and other vasoactive substance from basophils
and
mast cells. Since such reactions are life threatening, they must be recognized immediately and the appropriate treatment given.
The successful management of anaphylaxis requires a thorough understanding of this syndrome and the application of therapeutic agents.
The authors report a case of anaphylactoid response to thiopental in a 34 years old healthy male patient and briefly review the literature.
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